Fine-needle aspiration of the thyroid: an overview
Gia-Khanh Nguyen1, Mark W Lee1, Jody Ginsberg2, Tina Wragg1 and Darcy Bilodeau1
1Department of Laboratory Medicine and Pathology, University of Alberta Hospital, Edmonton, Alberta, Canada
2Department of Medicine (Endocrinology and Metabolism), University of Alberta Hospital, Edmonton, Alberta, Canada
CytoJournal 2005, 2:12 doi:10.1186/1742-6413-2-12
The electronic version of this article is the complete one and can be found online at: http://www.cytojournal.com/content/2/1/12
Received 19 May 2005
Accepted 29 June 2005
Published 29 June 2005
© 2005 Nguyen et al; licensee BioMed? Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Table of contents
- Indication and Goal of Thyroid FNA
- Contraindications and Complications of Thyroid FNA
- Procuration and Preparation of Cell Samples
- Specimen Adequacy
- Cytodiagnosis and Its Limitations
- Diagnostic Accuracy and Errors
- Adjunctive Diagnostic Value of Ancillary Techniques
- Copyright Information
Fine-needle aspiration (FNA) for cytologic evaluation of thyroid cancer was originally used by Martin and Ellis at New York Memorial Hospital for Cancer and Allied Diseases in 1930. However, this diagnostic procedure was subsequently found to have a limited value, and it was then discontinued at the above-mentioned institution. The thyroid FNA was not further developed and did not gain acceptance in the United States for nearly 50 years until the early 1980s when its diagnostic value was firmly demonstrated by Scandinavian investigators. The 1974 report by Crockford and Bain and the 1979 paper of Miller and Hamburger were apparently the first North American publications attesting to the value of thyroid FNA. This method of clinical investigation now is practiced worldwide and has become the cornerstone in the management of thyroid nodules (TN).
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